Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib

Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-sma...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Collier, Thomas Lee, Normandin, Marc D., Stephenson, Nickeisha A., Livni, Eli, Liang, Steven H., Wooten, Dustin W., Esfahani, Shadi A., Stabin, Michael G., Mahmood, Umar, Chen, Jianqing, Wang, Wei, Maresca, Kevin, Waterhouse, Rikki N., El Fakhri, Georges, Richardson, Paul, Vasdev, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472746/
https://ncbi.nlm.nih.gov/pubmed/28594000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15761
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky