Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib

Lorlatinib (PF-06463922) is a next-generation small-molecule inhibitor of the orphan receptor tyrosine kinase c-ros oncogene 1 (ROS1), which has a kinase domain that is physiologically related to anaplastic lymphoma kinase (ALK), and is undergoing Phase I/II clinical trial investigations for non-sma...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Collier, Thomas Lee, Normandin, Marc D., Stephenson, Nickeisha A., Livni, Eli, Liang, Steven H., Wooten, Dustin W., Esfahani, Shadi A., Stabin, Michael G., Mahmood, Umar, Chen, Jianqing, Wang, Wei, Maresca, Kevin, Waterhouse, Rikki N., El Fakhri, Georges, Richardson, Paul, Vasdev, Neil
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472746/
https://ncbi.nlm.nih.gov/pubmed/28594000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15761
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