Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia

The epichaperome is a new cancer target composed of hyperconnected networks of chaperome members that facilitate cell survival. Cancers with an altered chaperone configuration may be susceptible to epichaperome inhibitors. We developed a flow cytometry-based assay for evaluation and monitoring of ep...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: Sugita, Mayumi, Wilkes, David C., Bareja, Rohan, Eng, Kenneth W., Nataraj, Sarah, Jimenez-Flores, Reyna A., Yan, LunBiao, De Leon, Jeanne Pauline, Croyle, Jaclyn A., Kaner, Justin, Merugu, Swathi, Sharma, Sahil, MacDonald, Theresa Y., Noorzad, Zohal, Panchal, Palak, Pancirer, Danielle, Cheng, Shuhua, Xiang, Jenny Z., Olson, Luke, Van Besien, Koen, Rickman, David S., Mathew, Susan, Tam, Wayne, Rubin, Mark A., Beltran, Himisha, Sboner, Andrea, Hassane, Duane C., Chiosis, Gabriela, Elemento, Olivier, Roboz, Gail J., Mosquera, Juan Miguel, Guzman, Monica L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155064/
https://ncbi.nlm.nih.gov/pubmed/34040147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-021-00183-2
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