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Computational Study on Selective PDE9 Inhibitors on PDE9-Mg/Mg, PDE9-Zn/Mg, and PDE9-Zn/Zn Systems

PDE9 inhibitors have been studied to validate their potential to treat diabetes, neurodegenerative disorders, cardiovascular diseases, and erectile dysfunction. In this report, we have selected highly potent previously reported selective PDE9 inhibitors BAY73-6691R, BAY73-6691S, 28r, 28s, 3r, 3s, PF...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biomolecules
Hauptverfasser: Sivakumar, Dakshinamurthy, Mudedla, Sathishkumar, Jang, Seonghun, Kim, Hyunjun, Park, Hyunjin, Choi, Yonwon, Oh, Joongyo, Wu, Sangwook
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151263/
https://ncbi.nlm.nih.gov/pubmed/34068780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11050709
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