JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O(2)- and Fe(2+)-dependent enzyme, in mediating placental fibronectin processing and function. MALDI-TOF identified fibronectin as a novel...

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Udgivet i:Front Cell Dev Biol
Main Authors: Alahari, Sruthi, Farrell, Abby, Ermini, Leonardo, Park, Chanho, Sallais, Julien, Roberts, Sarah, Gillmore, Taylor, Litvack, Michael, Post, Martin, Caniggia, Isabella
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149756/
https://ncbi.nlm.nih.gov/pubmed/34055782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.652607
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