Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report that lysosome formation is markedly increased in trop...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Cell Dev Biol
Päätekijät: Ermini, Leonardo, Farrell, Abby, Alahari, Sruthi, Ausman, Jonathan, Park, Chanho, Sallais, Julien, Melland-Smith, Megan, Porter, Tyler, Edson, Michael, Nevo, Ori, Litvack, Michael, Post, Martin, Caniggia, Isabella
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2021
Aiheet:
Cell and Developmental Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130675/
https://ncbi.nlm.nih.gov/pubmed/34017832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.652651
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia