Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown. Here we report that lysosome formation is markedly increased in trop...

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Udgivet i:Front Cell Dev Biol
Main Authors: Ermini, Leonardo, Farrell, Abby, Alahari, Sruthi, Ausman, Jonathan, Park, Chanho, Sallais, Julien, Melland-Smith, Megan, Porter, Tyler, Edson, Michael, Nevo, Ori, Litvack, Michael, Post, Martin, Caniggia, Isabella
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130675/
https://ncbi.nlm.nih.gov/pubmed/34017832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.652651
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