Vaccine-induced ICOS(+)CD38(+) circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective humoral im...

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Vydáno v:Cell Rep Med
Hlavní autoři: Herati, Ramin Sedaghat, Silva, Luisa Victoria, Vella, Laura A., Muselman, Alexander, Alanio, Cecile, Bengsch, Bertram, Kurupati, Raj K., Kannan, Senthil, Manne, Sasikanth, Kossenkov, Andrew V., Canaday, David H., Doyle, Susan A., Ertl, Hildegund C.J., Schmader, Kenneth E., Wherry, E. John
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149371/
https://ncbi.nlm.nih.gov/pubmed/34095875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xcrm.2021.100262
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