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Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas
Advanced melanoma is a relentless tumor with a high metastatic potential. The combat of melanoma by using the targeted therapy is impeded because several major driver mutations fuel its growth (predominantly BRAF and NRAS). Both these mutated oncogenes strongly activate the MAPK (MEK/ERK) pathway. T...
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| 出版年: | Life (Basel) |
|---|---|
| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8148104/ https://ncbi.nlm.nih.gov/pubmed/34063141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/life11050424 |
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