BRAF and NRAS Mutations are Heterogeneous and Not Mutually Exclusive in Nodular Melanoma

Inhibitors of RAF inhibit the MAPK pathway that plays an important role in the development and progression of those melanoma carrying the V600E BRAF mutation, but there’s a subset of such patients who do not respond to the therapy. Various mechanisms of drug resistance have been proposed which inclu...

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Bibliografiske detaljer
Udgivet i:Appl Immunohistochem Mol Morphol
Main Authors: Chiappetta, Caterina, Proietti, Ilaria, Soccodato, Valentina, Puggioni, Chiara, Zaralli, Roberto, Pacini, Luca, Porta, Natale, Skroza, Nevena, Petrozza, Vincenzo, Potenza, Concetta, Della Rocca, Carlo, Di Cristofano, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2015
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Review Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482453/
https://ncbi.nlm.nih.gov/pubmed/24710085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000071
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