BRAF and NRAS Mutations are Heterogeneous and Not Mutually Exclusive in Nodular Melanoma

Inhibitors of RAF inhibit the MAPK pathway that plays an important role in the development and progression of those melanoma carrying the V600E BRAF mutation, but there’s a subset of such patients who do not respond to the therapy. Various mechanisms of drug resistance have been proposed which inclu...

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Detalhes bibliográficos
Publicado no:Appl Immunohistochem Mol Morphol
Main Authors: Chiappetta, Caterina, Proietti, Ilaria, Soccodato, Valentina, Puggioni, Chiara, Zaralli, Roberto, Pacini, Luca, Porta, Natale, Skroza, Nevena, Petrozza, Vincenzo, Potenza, Concetta, Della Rocca, Carlo, Di Cristofano, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2015
Assuntos:
Review Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482453/
https://ncbi.nlm.nih.gov/pubmed/24710085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000071
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