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BRAF and NRAS Mutations are Heterogeneous and Not Mutually Exclusive in Nodular Melanoma
Inhibitors of RAF inhibit the MAPK pathway that plays an important role in the development and progression of those melanoma carrying the V600E BRAF mutation, but there’s a subset of such patients who do not respond to the therapy. Various mechanisms of drug resistance have been proposed which inclu...
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| Publicado en: | Appl Immunohistochem Mol Morphol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Lippincott Williams & Wilkins
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4482453/ https://ncbi.nlm.nih.gov/pubmed/24710085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000071 |
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