BRAF and NRAS Mutations are Heterogeneous and Not Mutually Exclusive in Nodular Melanoma

Inhibitors of RAF inhibit the MAPK pathway that plays an important role in the development and progression of those melanoma carrying the V600E BRAF mutation, but there’s a subset of such patients who do not respond to the therapy. Various mechanisms of drug resistance have been proposed which inclu...

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Veröffentlicht in:Appl Immunohistochem Mol Morphol
Hauptverfasser: Chiappetta, Caterina, Proietti, Ilaria, Soccodato, Valentina, Puggioni, Chiara, Zaralli, Roberto, Pacini, Luca, Porta, Natale, Skroza, Nevena, Petrozza, Vincenzo, Potenza, Concetta, Della Rocca, Carlo, Di Cristofano, Claudio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2015
Schlagworte:
Review Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4482453/
https://ncbi.nlm.nih.gov/pubmed/24710085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAI.0000000000000071
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