Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabil...

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Xehetasun bibliografikoak
Argitaratua izan da:Matrix Biol
Egile Nagusiak: Marshall, Payton L., Nagy, Nadine, Kaber, Gernot, Barlow, Graham L., Ramesh, Amrit, Xie, Bryan J., Linde, Miles H., Haddock, Naomi L., Lester, Colin A., Tran, Quynh-Lam, de Vries, Christiaan, Hargil, Aviv, Malkovskiy, Andrey, Gurevich, Irina, Martinez, Hunter A., Kuipers, Hedwich F., Yadava, Koshika, Zhang, Xiangyue, Evanko, Stephen P., Gebe, John A., Wang, Xi, Vernon, Robert B., de la Motte, Carol, Wight, Thomas N., Engleman, Edgar G., Krams, Sheri M., Meyer, Everett, Bollyky, Paul L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147171/
https://ncbi.nlm.nih.gov/pubmed/33290836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2020.12.001
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