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Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabil...
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| Publicado no: | Matrix Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8147171/ https://ncbi.nlm.nih.gov/pubmed/33290836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2020.12.001 |
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