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Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection

A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU treatment reduces pericellular hyaluronan, destabil...

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Detalhes bibliográficos
Publicado no:Matrix Biol
Main Authors: Marshall, Payton L., Nagy, Nadine, Kaber, Gernot, Barlow, Graham L., Ramesh, Amrit, Xie, Bryan J., Linde, Miles H., Haddock, Naomi L., Lester, Colin A., Tran, Quynh-Lam, de Vries, Christiaan, Hargil, Aviv, Malkovskiy, Andrey, Gurevich, Irina, Martinez, Hunter A., Kuipers, Hedwich F., Yadava, Koshika, Zhang, Xiangyue, Evanko, Stephen P., Gebe, John A., Wang, Xi, Vernon, Robert B., de la Motte, Carol, Wight, Thomas N., Engleman, Edgar G., Krams, Sheri M., Meyer, Everett, Bollyky, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8147171/
https://ncbi.nlm.nih.gov/pubmed/33290836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2020.12.001
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