4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition

4-Methylumbelliferone (4-MU) inhibits hyaluronan (HA) synthesis and is an approved drug used for managing biliary spasm. However, rapid and efficient glucuronidation is thought to limit its utility for systemically inhibiting HA synthesis. In particular, 4-MU in mice has a short half-life, causing m...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Nagy, Nadine, Gurevich, Irina, Kuipers, Hedwich F., Ruppert, Shannon M., Marshall, Payton L., Xie, Bryan J., Sun, Wenchao, Malkovskiy, Andrey V., Rajadas, Jayakumar, Grandoch, Maria, Fischer, Jens W., Frymoyer, Adam R., Kaber, Gernot, Bollyky, Paul L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514619/
https://ncbi.nlm.nih.gov/pubmed/30914479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006166
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