4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition

4-Methylumbelliferone (4-MU) inhibits hyaluronan (HA) synthesis and is an approved drug used for managing biliary spasm. However, rapid and efficient glucuronidation is thought to limit its utility for systemically inhibiting HA synthesis. In particular, 4-MU in mice has a short half-life, causing m...

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Vydáno v:J Biol Chem
Hlavní autoři: Nagy, Nadine, Gurevich, Irina, Kuipers, Hedwich F., Ruppert, Shannon M., Marshall, Payton L., Xie, Bryan J., Sun, Wenchao, Malkovskiy, Andrey V., Rajadas, Jayakumar, Grandoch, Maria, Fischer, Jens W., Frymoyer, Adam R., Kaber, Gernot, Bollyky, Paul L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514619/
https://ncbi.nlm.nih.gov/pubmed/30914479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006166
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