Hyaluronan content governs tissue stiffness in pancreatic islet inflammation

We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in governing the mechanical properties of inflamed tissues. We recently reported that insulitis in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly hygroscopic polymer. Usin...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nagy, Nadine, de la Zerda, Adi, Kaber, Gernot, Johnson, Pamela Y., Hu, Kenneth H., Kratochvil, Michael J., Yadava, Koshika, Zhao, Wenting, Cui, Yi, Navarro, Guadalupe, Annes, Justin P., Wight, Thomas N., Heilshorn, Sarah C., Bollyky, Paul L., Butte, Manish J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767862/
https://ncbi.nlm.nih.gov/pubmed/29183997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000148
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