Hyaluronan content governs tissue stiffness in pancreatic islet inflammation

We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in governing the mechanical properties of inflamed tissues. We recently reported that insulitis in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly hygroscopic polymer. Usin...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Nagy, Nadine, de la Zerda, Adi, Kaber, Gernot, Johnson, Pamela Y., Hu, Kenneth H., Kratochvil, Michael J., Yadava, Koshika, Zhao, Wenting, Cui, Yi, Navarro, Guadalupe, Annes, Justin P., Wight, Thomas N., Heilshorn, Sarah C., Bollyky, Paul L., Butte, Manish J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Glycobiology and Extracellular Matrices
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767862/
https://ncbi.nlm.nih.gov/pubmed/29183997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000148
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