Hyaluronan content governs tissue stiffness in pancreatic islet inflammation

We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in governing the mechanical properties of inflamed tissues. We recently reported that insulitis in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly hygroscopic polymer. Usin...

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Vydáno v:J Biol Chem
Hlavní autoři: Nagy, Nadine, de la Zerda, Adi, Kaber, Gernot, Johnson, Pamela Y., Hu, Kenneth H., Kratochvil, Michael J., Yadava, Koshika, Zhao, Wenting, Cui, Yi, Navarro, Guadalupe, Annes, Justin P., Wight, Thomas N., Heilshorn, Sarah C., Bollyky, Paul L., Butte, Manish J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767862/
https://ncbi.nlm.nih.gov/pubmed/29183997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000148
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