Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here, we have demonstrated that HA is critical for the...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y., Gebe, John A., Preisinger, Anton, Falk, Ben A., Sunkari, Vivekananda G., Gooden, Michel D., Vernon, Robert B., Bogdani, Marika, Kuipers, Hedwich F., Day, Anthony J., Campbell, Daniel J., Wight, Thomas N., Bollyky, Paul L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607113/
https://ncbi.nlm.nih.gov/pubmed/26368307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79271
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