Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here, we have demonstrated that HA is critical for the...

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Udgivet i:J Clin Invest
Main Authors: Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y., Gebe, John A., Preisinger, Anton, Falk, Ben A., Sunkari, Vivekananda G., Gooden, Michel D., Vernon, Robert B., Bogdani, Marika, Kuipers, Hedwich F., Day, Anthony J., Campbell, Daniel J., Wight, Thomas N., Bollyky, Paul L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607113/
https://ncbi.nlm.nih.gov/pubmed/26368307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79271
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