Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here, we have demonstrated that HA is critical for the...

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Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y., Gebe, John A., Preisinger, Anton, Falk, Ben A., Sunkari, Vivekananda G., Gooden, Michel D., Vernon, Robert B., Bogdani, Marika, Kuipers, Hedwich F., Day, Anthony J., Campbell, Daniel J., Wight, Thomas N., Bollyky, Paul L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607113/
https://ncbi.nlm.nih.gov/pubmed/26368307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79271
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