Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis

We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients with type 1 diabetes (T1D), but the relevance of these deposits to disease was unclear. Here, we have demonstrated that HA is critical for the...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Nagy, Nadine, Kaber, Gernot, Johnson, Pamela Y., Gebe, John A., Preisinger, Anton, Falk, Ben A., Sunkari, Vivekananda G., Gooden, Michel D., Vernon, Robert B., Bogdani, Marika, Kuipers, Hedwich F., Day, Anthony J., Campbell, Daniel J., Wight, Thomas N., Bollyky, Paul L.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607113/
https://ncbi.nlm.nih.gov/pubmed/26368307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79271
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