Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo

Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis. Natural Treg cells (nTregs), described as CD4(+)CD25(+)FOXP3(+), are generated in the t...

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Publicado no:Biomedicines
Main Authors: Gallego-Valle, Jorge, Gil-Manso, Sergio, Pita, Ana, Bernaldo-de-Quirós, Esther, López-Esteban, Rocío, Martínez-Bonet, Marta, Pérez-Fernández, Verónica Astrid, Pérez-Caballero, Ramón, Pardo, Carlos, Gil-Jaurena, Juan-Miguel, Correa-Rocha, Rafael, Pion, Marjorie
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146103/
https://ncbi.nlm.nih.gov/pubmed/33922629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9050461
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