Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation

CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage. Induction immunosuppression is commonly used in solid organ transplantation and can include antibodies blocking CD25. However, regulatory T cells (Tregs) also rely on CD25 for the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: López-Abente, Jacobo, Martínez-Bonet, Marta, Bernaldo-de-Quirós, Esther, Camino, Manuela, Gil, Nuria, Panadero, Esther, Gil-Jaurena, Juan Miguel, Clemente, Maribel, Urschel, Simon, West, Lori, Pion, Marjorie, Correa-Rocha, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803770/
https://ncbi.nlm.nih.gov/pubmed/33436905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-80567-9
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