Conversion of the death inhibitor ARC to a killer activates pancreatic β-cell death in diabetes

Loss of insulin-secreting pancreatic β-cells through apoptosis contributes to the progression of type 2 diabetes, but underlying mechanisms remain elusive. Here we identify a pathway in which the cell death inhibitor ARC paradoxically becomes a killer during diabetes. While cytoplasmic ARC maintains...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: McKimpson, Wendy M., Chen, Yun, Irving, James A., Zheng, Min, Weinberger, Jeremy, Lek Wen Tan, Wilson, Tiang, Zenia, Jagger, Alistair M., Chua, Streamson C., Pessin, Jeffrey E., Foo, Roger S.-Y., Lomas, David A., Kitsis, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146085/
https://ncbi.nlm.nih.gov/pubmed/33667344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2021.02.011
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