The Apoptosis Inhibitor ARC Alleviates the ER Stress Response to Promote β-Cell Survival

Type 2 diabetes involves insulin resistance and β-cell failure leading to inadequate insulin secretion. An important component of β-cell failure is cell loss by apoptosis. Apoptosis repressor with caspase recruitment domain (ARC) is an inhibitor of apoptosis that is expressed in cardiac and skeletal...

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Detalhes bibliográficos
Main Authors: McKimpson, Wendy M., Weinberger, Jeremy, Czerski, Lech, Zheng, Min, Crow, Michael T., Pessin, Jeffrey E., Chua, Streamson C., Kitsis, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526036/
https://ncbi.nlm.nih.gov/pubmed/22933109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0504
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