Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia

In acute myeloid leukemia (AML), about 25–30% of patients harbor a constitutively active receptor tyrosine kinase (RTK) FLT3 encoded by a FLT3 allele harboring internal tandem duplication (FLT3-ITD) mutation. The presence of FLT3-ITD correlates with poor prognosis in AML and it makes FLT3 an attract...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Park, I-K, Mundy-Bosse, B, Whitman, SP, Zhang, X, Warner, SL, Bearss, DJ, Blum, W, Marcucci, G, Caligiuri, MA
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8145983/
https://ncbi.nlm.nih.gov/pubmed/26172401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.147
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