Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target

Approximately 20% to 25% of patients with acute myeloid leukemia (AML) have a constitutively activated FLT3-internal tandem duplication (FLT3-ITD), and these patients exhibit a poor prognosis. Here, we report that Axl, a receptor tyrosine kinase (RTK) overexpressed and constitutively active in human...

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Detalhes bibliográficos
Main Authors: Park, Il-Kyoo, Mishra, Anjali, Chandler, Jason, Whitman, Susan P., Marcucci, Guido, Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596966/
https://ncbi.nlm.nih.gov/pubmed/23321254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-444018
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