Elevated frequencies of leukemic myeloid and plasmacytoid dendritic cells in acute myeloid leukemia with the FLT3 internal tandem duplication

Some 30% of acute myeloid leukemia (AML) patients display an internal tandem duplication (ITD) mutation in the FMS-like tyrosine kinase 3 (FLT3) gene. FLT3-ITDs are known to drive hematopoietic stem cells towards FLT3 ligand independent growth, but the effects on dendritic cell (DC) differentiation...

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Autors principals: Rickmann, Mareike, Krauter, Juergen, Stamer, Kathrin, Heuser, Michael, Salguero, Gustavo, Mischak-Weissinger, Eva, Ganser, Arnold, Stripecke, Renata
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150660/
https://ncbi.nlm.nih.gov/pubmed/21520003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-011-1231-2
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