Characteristics and Prognosis of Adult Acute Myeloid Leukemia with Internal Tandem Duplication in the FLT3 Gene

Objectives: Constitutive activation of the fms-like tyrosine kinase 3 (FLT3) receptor by internal tandem duplication (ITD) of the juxtamembrane region has been described in patients with acute myeloid leukemia. FLT3/ITDs are present in about 20-30% of all acute myeloid leukemia cases. It has been sh...

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Autores principales: Adhra Al-Mawali, David Gillis, Ian Lewis
Formato: Artigo
Lenguaje:Inglês
Publicado: Oman Medical Specialty Board 2013-11-01
Colección:Oman Medical Journal
Materias:
Acute Myeloid Leukemia
M1
FLT3 gene
Tandem duplication
Prognosis.
Acceso en línea:http://www.omjournal.org/fultext_PDF.aspx?DetailsID=449&type=fultext
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