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Reversible RNA acylation for control of CRISPR–Cas9 gene editing
We report the development of post-transcriptional chemical methods that enable control over CRISPR–Cas9 gene editing activity both in in vitro assays and in living cells. We show that an azide-substituted acyl imidazole reagent (NAI-N(3)) efficiently acylates CRISPR single guide RNAs (sgRNAs) in 20...
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| Udgivet i: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Royal Society of Chemistry
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8145180/ https://ncbi.nlm.nih.gov/pubmed/34084356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03639c |
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