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RNA Cloaking by Reversible Acylation

We describe a selective and mild chemical approach to controlling RNA hybridization, folding, and enzyme interactions. Reaction of RNAs in aqueous buffer with an azide-substituted acylating agent (100-200 mM) yields several 2′-OH acylations per RNA strand in as little as 10 min. This poly-acylated (...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Kadina, Anastasia, Kietrys, Anna M., Kool, Eric T.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842138/
https://ncbi.nlm.nih.gov/pubmed/29370460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201708696
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