Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes

The methyltransferases MLL3 and MLL4 primarily catalyze the monomethylation of histone H3 lysine 4 (H3K4) on enhancers to regulate cell-type-specific gene expression and cell fate transition. MLL3 and MLL4 share almost identical binding partners and biochemical activities, but perform specific and n...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Zheng, Yongxin, Huang, Yinping, Mencius, Jun, Li, Yanjing, Zhao, Lijie, Luo, Wanting, Chen, Yong, Quan, Shu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144669/
https://ncbi.nlm.nih.gov/pubmed/33823156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100635
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