Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma

BACKGROUND: The adoptive transfer of tumor-infiltrating lymphocytes (TIL) has demonstrated robust efficacy in metastatic melanoma patients. Tumor antigen–loaded dendritic cells (DCs) are believed to optimally activate antigen-specific T lymphocytes. We hypothesized that the combined transfer of TIL,...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Saberian, Chantal, Amaria, Rodabe N., Najjar, Amer M., Radvanyi, Laszlo G., Haymaker, Cara L., Forget, Marie-Andrée, Bassett, Roland L., Faria, Silvana C., Glitza, Isabella C., Alvarez, Enrique, Parshottam, Sapna, Prieto, Victor, Lizée, Gregory, Wong, Michael K., McQuade, Jennifer L., Diab, Adi, Yee, Cassian, Tawbi, Hussein A., Patel, Sapna, Shpall, Elizabeth J., Davies, Michael A., Hwu, Patrick, Bernatchez, Chantale
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Clinical/Translational Cancer Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144048/
https://ncbi.nlm.nih.gov/pubmed/34021033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002449
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