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Sp1 is a substrate of Keap1 and regulates the activity of CRL4A(WDR23) ubiquitin ligase toward Nrf2
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a critical transcription factor that orchestrates cellular responses to oxidative stress. Because the dysregulation of Nrf2 has been implicated in many diseases, precise regulation of its protein level is crucial for maintaining homeostasis. Kelc...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8141886/ https://ncbi.nlm.nih.gov/pubmed/33895141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100704 |
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