UBXN7 cofactor of CRL3(KEAP1) and CRL2(VHL) ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins

UBXN7 is a cofactor protein that provides a scaffold for both CRL3(KEAP1) and CRL2(VHL) ubiquitin ligase complexes involved in the regulation of the NRF2 and HIF-1α protein levels respectively. NRF2 and HIF-1α are surveillance transcription factors that orchestrate the cellular response to oxidative...

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Detalles Bibliográficos
Publicado en:Biochim Biophys Acta Mol Cell Res
Main Authors: Di Gregorio, Jacopo, Cilenti, Lucia, Ambivero, Camilla T., Andl, Thomas, Liao, Ronglih, Zervos, Antonis S.
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7882025/
https://ncbi.nlm.nih.gov/pubmed/33444648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2021.118963
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