Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

Incompletely-synthesized nascent-chains obstructing large ribosomal subunits are targeted for degradation by Ribosome-associated Quality Control (RQC). In bacterial RQC, RqcH marks the nascent-chains with C-terminal alanine (Ala) tails that are directly recognized by proteasome-like proteases, where...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Thrun, Anna, Garzia, Aitor, Kigoshi-Tansho, Yu, Patil, Pratik R., Umbaugh, Charles S., Dallinger, Teresa, Liu, Jia, Kreger, Sylvia, Patrizi, Annarita, Cox, Gregory A., Tuschl, Thomas, Joazeiro, Claudio A.P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8141035/
https://ncbi.nlm.nih.gov/pubmed/33909987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.03.004
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