Effects of Altering Heparan Sulfate Proteoglycan Binding and Capsid Hydrophilicity on Retinal Transduction by Adeno-associated Virus

Adeno-associated viruses (AAVs) have recently emerged as the leading vector for retinal gene therapy. However, AAV vectors that are capable of achieving clinically relevant levels of transgene expression and widespread retinal transduction are still an unmet need. Using rationally designed AAV2-base...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Crosson, Sean M., Bennett, Antonette, Fajardo, Diego, Peterson, James J., Zhang, Hangning, Li, Wei, Leahy, Matthew T., Jennings, Colin K., Boyd, Ryan F., Boye, Sanford L., Agbandje-McKenna, Mavis, Boye, Shannon E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2021
Aiheet:
Gene Delivery
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139652/
https://ncbi.nlm.nih.gov/pubmed/33658343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02440-20
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