Effects of Altering Heparan Sulfate Proteoglycan Binding and Capsid Hydrophilicity on Retinal Transduction by Adeno-associated Virus

Adeno-associated viruses (AAVs) have recently emerged as the leading vector for retinal gene therapy. However, AAV vectors that are capable of achieving clinically relevant levels of transgene expression and widespread retinal transduction are still an unmet need. Using rationally designed AAV2-base...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Crosson, Sean M., Bennett, Antonette, Fajardo, Diego, Peterson, James J., Zhang, Hangning, Li, Wei, Leahy, Matthew T., Jennings, Colin K., Boyd, Ryan F., Boye, Sanford L., Agbandje-McKenna, Mavis, Boye, Shannon E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139652/
https://ncbi.nlm.nih.gov/pubmed/33658343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02440-20
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