Effects of Altering Heparan Sulfate Proteoglycan Binding and Capsid Hydrophilicity on Retinal Transduction by Adeno-associated Virus

Adeno-associated viruses (AAVs) have recently emerged as the leading vector for retinal gene therapy. However, AAV vectors that are capable of achieving clinically relevant levels of transgene expression and widespread retinal transduction are still an unmet need. Using rationally designed AAV2-base...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Crosson, Sean M., Bennett, Antonette, Fajardo, Diego, Peterson, James J., Zhang, Hangning, Li, Wei, Leahy, Matthew T., Jennings, Colin K., Boyd, Ryan F., Boye, Sanford L., Agbandje-McKenna, Mavis, Boye, Shannon E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Gene Delivery
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139652/
https://ncbi.nlm.nih.gov/pubmed/33658343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02440-20
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