Physiologically-Based Pharmacokinetic Modeling Characterizes the CYP3A-Mediated Drug-Drug Interaction Between Fluconazole and Sildenafil in Infants

Physiologically-based pharmacokinetic (PBPK) modeling can potentially predict pediatric drug-drug interactions (DDIs) when clinical DDI data are limited. In infants for whom treatment of pulmonary hypertension and prevention or treatment of invasive candidiasis are indicated, sildenafil with flucona...

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Veröffentlicht in:Clin Pharmacol Ther
Hauptverfasser: Salerno, Sara N., Edginton, Andrea, Gerhart, Jacqueline G., Laughon, Matthew M., Ambalavanan, Namasivayam, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mills, Mary, Martz, Karen, Gonzalez, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138939/
https://ncbi.nlm.nih.gov/pubmed/32691891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1990
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