Population pharmacokinetics of sildenafil in extremely premature infants

AIMS: To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. METHODS: We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and < 365 postnatal day...

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Publicado en:Br J Clin Pharmacol
Main Authors: Gonzalez, Daniel, Laughon, Matthew M., Smith, P. Brian, Ge, Shufan, Ambalavanan, Namasivayam, Atz, Andrew, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Gaedigk, Roger, Mills, Mary, Cohen‐Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955411/
https://ncbi.nlm.nih.gov/pubmed/31475367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14111
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