Population pharmacokinetics of sildenafil in extremely premature infants

AIMS: To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. METHODS: We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and < 365 postnatal day...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Clin Pharmacol
Auteurs principaux: Gonzalez, Daniel, Laughon, Matthew M., Smith, P. Brian, Ge, Shufan, Ambalavanan, Namasivayam, Atz, Andrew, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Gaedigk, Roger, Mills, Mary, Cohen‐Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955411/
https://ncbi.nlm.nih.gov/pubmed/31475367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14111
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