Population pharmacokinetics of sildenafil in extremely premature infants

AIMS: To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. METHODS: We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and < 365 postnatal day...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Gonzalez, Daniel, Laughon, Matthew M., Smith, P. Brian, Ge, Shufan, Ambalavanan, Namasivayam, Atz, Andrew, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Gaedigk, Roger, Mills, Mary, Cohen‐Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955411/
https://ncbi.nlm.nih.gov/pubmed/31475367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14111
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