Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Three-dimensional (3D) microphysiological systems (MPSs) mimicking human organ function in vitro are an emerging alternative to conventional monolayer cell culture and animal models for drug development. Human induced pluripotent stem cells (hiPSCs) have the potential to capture the diversity of hum...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lee-Montiel, Felipe T., Laemmle, Alexander, Charwat, Verena, Dumont, Laure, Lee, Caleb S., Huebsch, Nathaniel, Okochi, Hideaki, Hancock, Matthew J., Siemons, Brian, Boggess, Steven C., Goswami, Ishan, Miller, Evan W., Willenbring, Holger, Healy, Kevin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138446/
https://ncbi.nlm.nih.gov/pubmed/34025426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.667010
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