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Immunomodulatory Effects of BRAF, MEK, and CDK4/6 Inhibitors: Implications for Combining Targeted Therapy and Immune Checkpoint Blockade for the Treatment of Melanoma

The recent advent of targeted and immune-based therapies has revolutionized the treatment of melanoma and transformed outcomes for patients with metastatic disease. The majority of patients develop resistance to the current standard-of-care targeted therapy, dual BRAF and MEK inhibition, prompting e...

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Publicat a:Front Immunol
Autors principals: Lelliott, Emily J., McArthur, Grant A., Oliaro, Jane, Sheppard, Karen E.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137893/
https://ncbi.nlm.nih.gov/pubmed/34025662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.661737
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