Reprogramming transcription factors Oct4 and Sox2 induces a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells

A subset of stem-like tumor-propagating cells in GBM (GSC) underlies tumor propagation, therapeutic resistance and tumor recurrence. Immune evasion is critical for GSCs to carry out these functions. However, the molecular mechanisms employed by GSCs to escape anti-tumor immunity remain largely unkno...

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Vydáno v:Cancer Res
Hlavní autoři: Ma, Tengjiao, Hu, Chengchen, Lal, Bachchu, Zhou, Weiqiang, Ma, Yongxin, Ying, Mingyao, Prinos, Panagiotis, Quiñones-Hinojosa, Alfredo, Lim, Michael, Laterra, John, Li, Yunqing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137560/
https://ncbi.nlm.nih.gov/pubmed/33574085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2489
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