Reprogramming transcription factors Oct4 and Sox2 induces a BRD-dependent immunosuppressive transcriptome in GBM-propagating cells

A subset of stem-like tumor-propagating cells in GBM (GSC) underlies tumor propagation, therapeutic resistance and tumor recurrence. Immune evasion is critical for GSCs to carry out these functions. However, the molecular mechanisms employed by GSCs to escape anti-tumor immunity remain largely unkno...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Ma, Tengjiao, Hu, Chengchen, Lal, Bachchu, Zhou, Weiqiang, Ma, Yongxin, Ying, Mingyao, Prinos, Panagiotis, Quiñones-Hinojosa, Alfredo, Lim, Michael, Laterra, John, Li, Yunqing
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137560/
https://ncbi.nlm.nih.gov/pubmed/33574085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2489
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