The cancer-associated ATM R3008H mutation reveals the link between ATM activation and its exchange

ATM kinase is a tumor suppressor and a master regulator of the DNA damage response. Most cancer-associated alterations to ATM are missense mutations at the PI3-kinase regulatory domain (PRD) or the kinase domain. Expression of kinase-dead ATM protein solely accelerates lymphomagenesis beyond ATM los...

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Publicat a:Cancer Res
Autors principals: Milanovic, Maja, Houghton, Lisa M., Menolfi, Demis, Lee, Ji-Hoon, Yamamoto, Kenta, Li, Yang, Lee, Brian J., Xu, Jun, Estes, Verna M., Wang, Dong, Mckinnon, Peter J., Paull, Tanya T., Zha, Shan
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137556/
https://ncbi.nlm.nih.gov/pubmed/33239428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-2447
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