Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA

ATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss. Mouse model expressing kinase-dead ATR (Atr(+/KD)), but not loss of ATR (Atr(+/−)), displays ssDNA-dependent defects at the non-homologous re...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Menolfi, Demis, Jiang, Wenxia, Lee, Brian J., Moiseeva, Tatiana, Shao, Zhengping, Estes, Verna, Frattini, Mark G., Bakkenist, Christopher J., Zha, Shan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297235/
https://ncbi.nlm.nih.gov/pubmed/30559436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07798-3
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