An ATR and CHK1 kinase signaling mechanism that limits origin firing during unperturbed DNA replication

DNA damage-induced signaling by ATR and CHK1 inhibits DNA replication, stabilizes stalled and collapsed replication forks, and mediates the repair of multiple classes of DNA lesions. We and others have shown that ATR kinase inhibitors, three of which are currently undergoing clinical trials, induce...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Moiseeva, Tatiana N., Yin, Yandong, Calderon, Michael J., Qian, Chenao, Schamus-Haynes, Sandra, Sugitani, Norie, Osmanbeyoglu, Hatice U., Rothenberg, Eli, Watkins, Simon C., Bakkenist, Christopher J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613105/
https://ncbi.nlm.nih.gov/pubmed/31209037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903418116
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