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ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells. ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5680267/ https://ncbi.nlm.nih.gov/pubmed/29123096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01401-x |
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