Modifications to the Framework Regions Eliminate Chimeric Antigen Receptor Tonic Signaling

Chimeric antigen receptor (CAR) tonic signaling, defined as spontaneous activation and release of proinflamatory cytokines by CAR-T cells, is considered a negative attribute because it leads to impaired antitumor effects. Here, we report that CAR tonic signaling is caused by the intrinsic instabilit...

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Publicado no:Cancer Immunol Res
Main Authors: Landoni, Elisa, Fucá, Giovanni, Wang, Jian, Chirasani, Venkat R., Yao, Zhiyuan, Dukhovlinova, Elena, Ferrone, Soldano, Savoldo, Barbara, Hong, Lee K., Shou, Peishun, Musio, Silvia, Padelli, Francesco, Finocchiaro, Gaetano, Droste, Miriam, Kuhlman, Brian, Shamshiev, Abdijapar, Pellegatta, Serena, Dokholyan, Nikolay V., Dotti, Gianpietro
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8137530/
https://ncbi.nlm.nih.gov/pubmed/33547226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0451
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