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Fully human antibody V(H) domains to generate mono and bispecific CAR to target solid tumors
BACKGROUND: Chimeric antigen receptor (CAR) T cells are effective in B-cell malignancies. However, heterogeneous antigen expression and antigen loss remain important limitations of targeted immunotherapy in solid tumors. Therefore, targeting multiple tumor-associated antigens simultaneously is expec...
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| Publicado no: | J Immunother Cancer |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Publishing Group
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8021891/ https://ncbi.nlm.nih.gov/pubmed/33795386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-002173 |
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