TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers simultaneously could result in better therapeutic...

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Bibliographic Details
Main Authors: Zakaria Grada, Meenakshi Hegde, Tiara Byrd, Donald R Shaffer, Alexia Ghazi, Vita S Brawley, Amanda Corder, Kurt Schönfeld, Joachim Koch, Gianpietro Dotti, Helen E Heslop, Stephen Gottschalk, Winfried S Wels, Matthew L Baker, Nabil Ahmed
Format: Artigo
Language:Inglês
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
bispecific chimeric antigen receptor
CAR
cancer immunotherapy
molecular modeling
T-cell therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301640
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